PolyLyser-12™ – The Future of Sample Prep Starts Here
PolyLyser-12™ is the fastest benchtop bead mill homogenizer ever built. It is uniquely engineered to shatter biological and environmental samples with speed, consistency, and molecular precision using our remarkable proprietary HyperLysis Technology™ i . Designed by the same team that invented FastPrep®, this next-gen platform offers true cryogenic capability built-in, not bolted on, and sets a new standard of performance across genomics, transcriptomics, metabolomics, and microbiome studies.
Key Features at a Glance:
| Features | PolyLyser-12™ |
| Speed | 5–10 second lysis time (90% faster than conventional homogenizers) |
| Cryogenic Lysis | Standard – no accessories needed |
| Sample Platforms, |
12 x 2 ml standard screw lid tubes 2 x 15 ml standard screw lid tubes 2 x 50 ml standard screw lid tubes |
| Touchscreen Interface | Yes – with programmable memory recall |
| Cooling Protection | Yes – designed to preserve heat-sensitive RNA & proteins |
| Dimensions | Compact benchtop footprint |
| Price | Launch special: $6,900 |
| Manufacturing | Designed & assembled in Tustin, California, USA |
What Makes PolyLyser™ Different?
✅ Unmatched Speed
Typical lysing occurs in 5 – 10 seconds as opposed to 30 – 60 seconds with traditional systems. This remarkable lysing time is due to the incredible grinding efficiency of the HyperLysing Technology. Save hours per day in high-throughput workflows.
✅ True Cryogenic Lysis – Included Standard
Cryo-grinding isn’t an upgrade. It is a standard feature of each of the PolyLyser lysing platfoms, which have an integrated cryogenic system that enables rapid lysis of frozen or temperature-sensitive samples without thermal degradation. Same adapter is used for the room temperature lysis too, so no need for switchable heads.
✅ 12-Sample Throughput in Standard Tubes
No special plastics, caps, or adapters needed. PolyLyser works with any standard 2 mL screw-capped lysing matrix tube — including all commercially available glass, garnet, zirconia, and ceramic bead kits.
✅ Touchscreen Control
Simple, smart, and intuitive touchscreen with programmable memory to store and recall lysis profile.
✅ RNA/Protein Integrity First
Short run times + cryo-compatibility = less heat = better quality RNA, long gDNA, enzymes, and fragile metabolites.
Application Areas
- DNA, RNA & protein extraction from plants, animals, fungi, and bacteria
- Cryogenic lysis of snap-frozen biopsies and tissues
- Microbiome profiling from gut, fecal, and soil samples
- Spore lysis and pathogen detection
- Metabolomics & proteomics sample prep
- Chromatin shearing for ChIP and NGS
- Clinical, forensics, and archaeological samples
- Environmental and paleontological sample disruption
Who It’s For
- Molecular Biologists protecting RNA from thermal decay
- Microbiome Scientists working with fecal and soil DNA
- Core Lab Managers handling high-throughput pipelines
- Educators updating student labs with future-ready sample prep
- Pharma/Biotech Researchers requiring reproducible lysis for omics workflows
Compatible With All Downstream Workflows
Use PolyLyser with your current:
- TRIzol® or magnetic bead kits
- Column-based extractions
- qPCR, RT-qPCR, NGS, or RNA-seq
- Western blots or mass spectrometry
- Microbiome, metagenomic, and proteomic analyses
PolyLyser™ vs. Other Machines
| Feature | PolyLyser™ | FastPrep-24 5G | Bead Ruptor 12 | Precellys 24 Touch |
| Typical Lysis Time | 5–10 sec | 30–40 sec | 45–60 sec | 30–60 sec |
| Cryogenic Ready | Standard | Optional | ❌ | Optional |
| Tube Format | 2 ml tubes,
4.5 ml tubes, 15 ml tubes, and 50 ml tubes |
2 ml tubes,
4.5 ml tubes, 15 ml tubes, and 50 ml tubes |
1.5–2 mL | 2 mL |
| RNA/Protein Safety | High | Moderate | Moderate | Moderate |
| Launch Price | $6,900.00 | ~$7,500 | ~$8,000 | ~$10,000+ |
Final Word: Why Settle for Yesterday’s Tech?
You wouldn’t use a flip phone in 2025 — why use a 20+year-old homogenizer design?
PolyLyser™ delivers modern speed, built-in cryogenic control, and real-world compatibility in a compact footprint — all at a price every lab can afford.
Ready to Order or Get a Quote?
Visit rotaprep.com/polylyser
No obligation — just the fastest, most future-ready homogenizer on the planet.
